Latics manager Lee Johnson is hoping to capitalise on a Brentford side that lost to Rotherham United on Tuesday night.
The Bees were comfortably beaten 3-0 midweek and with Latics on a good run of form at the moment, the gaffer is hoping Brentford's nerves get to them.
He said: "It's getting to that point in the season where you think you're over the line, and you're not. You then start to get a bit edgy and panicky and hopefully we'll be able to capitalise on Brentford on Saturday."
Latics earned a point on Tuesday through a last minute goal and Johnson was delighted for his players in what he described as "a good point".
"It was a solid performance where we had a lot of chances," the boss commented. "I was pleased with the spirit of the lads and it was a great goal from Korey which put the shine on a great performance.
"It was a good finish and it was needed at the time because of the chances we already had."
Korey Smith hit a goal of the season contender, smashing home from 30 yards, but the gaffer admitted he is weary of the midfielder's fitness ahead of the game.
Johnson said: "We've got to keep assessing Korey on a daily basis. We've got to make sure to nurse everyone back to fitness but hopefully everyone will come through fine."
Saturday sees a return to Boundary Park for former defender James Tarkowski; a player who the manager knows well.
"I'd expect him to play," expressed the 32-year-old. "I'm sure he'll be involved and I hope to see him involved because we know a lot about him."
The manager finished his press conference by praising the superb support from the Latics fans who made the trip to London on Tuesday night.
He said: "It was a great effort by supporters and it is really appreciated. I'd say our 250 fans bullied the Orient fans and that's the sort of mentality we want around the club."