Manager David Dunn will ring the changes as he takes his side to Sheffield United in the second round of the FA Cup on Saturday.
Latics have had a dip in form over the last couple of weeks, something which the manager puts down to the rigid 4-4-2 formation.
However, Dunn is expected to adopt the 4-2-3-1 approach, something he feels he should never have strayed from.
He said: "There will be changes that’s for sure. If I’m being honest with myself, I have gone off with what I believe in over the last few weeks for various reasons but I’ll be back to what I think is the best way to go for this football club.
"There are a few individuals that have been left out that can feel unfortunate. The formation we played didn’t suit them and they will be back in. It will be a chance for them to stamp their authority on proceedings and stop the rot. We want to put the three losses that hurt the club to bed.”
With league form out of the window and the third round in sight, Bramall Lane is the destination for Dunn’s men on Saturday, and the Blades are a team he has watched a lot of.
"I’ve been to watch them a couple of times this season and they have been dangerous every time I have seen them. They have a strong squad and have a really good manager so we’ve got to set our stall out and get a result there,” Dunn commented.
"I thought we were good that game. I was very pleased with the performance but disappointed with their goal. Overall it was a decent afternoon and one that we could have turned into a win rather than a draw.”
With certain off the field problems going on recently, the 35-year-old is keen to get back to matters on the field.
“There is no getting away from it, it has been a difficult time but all we want to do is focus on the football,” he said. "That’s all we can affect, all the other stuff we can’t affect. We have to roll our sleeves up. We need everybody at the club and at the club on board, hopefully we can change it around.”
Watch the full interview on Latics PlayerHD.