Oldham Athletic fell to a 1-3 defeat as Hallam Hope, Ashley Nadeson and Jack Sowerby all scored to secure the three points for the visitors.
Ishmael Miller did pull one back for Latics, but it wasn’t enough as the four-game unbeaten run was ended.
Latics struggled to get going in the opening exchanges and Carlisle almost took an early lead after Hope nicked the ball off George Edmundson on the edge of the Oldham penalty area.
Hope played it to Sowerby whose shot was blocked by Sam Graham before Macaulay Gillesphey dragged his shot just wide of the post.
Both teams were lined up in a 3-5-2 formation which made the game a tight affair, but Hope found himself clear of the Latics backline before Edmundson recovered well to snuff out the danger.
Frankie Bunn’s men created their first opportunity after Andy Taylor’s freekick was defended well by Mike Jones as it looked destined to find Peter Clarke.
The Cumbrians took the lead after Jerry Yates’ cross found Gillesphey at the back post and he in turn headed back across to Hope who had the simple task of heading in from two yards.
Latics responded well as Dan Gardner dragged a shot wide on his left foot, before Ishmael Miller powered his way into the box and forced a good save from goalkeeper Adam Collin.
Sowerby then put an effort wide before Miller once again got in down the right and produced a good cross which was somehow scrambled away by the Carlisle defence and Latics went in at half-time a goal down.
Carlisle doubled their lead ten minutes into the second half as Hope crossed in for Nadeson who smashed the ball into the roof of Iversen’s net.
It was three a minute later as the ball was played into Sowerby who turned well in the box before placing it into the bottom corner.
Oldham looked to respond as substitute Callum Lang forced a save from Collin, before Surridge headed wide an Andy Taylor cross.
Latics had one back when Lang played Miller through on goal and he slotted home for his second goal of the season.
Lang himself forced a fine save out of Collin who tipped over the Wigan loanee’s header over his own crossbar as Latics couldn’t force another home comeback.
Bunn’s men will have to pick themselves up when they travel to Bradford City in the Checkatrade Trophy on Tuesday night.
Attendance 4739 (679 Away)
Oldham Athletic
Iversen, Graham (Branger-Engone 60’), Clarke ©, Edmundson, Hunt, Taylor, Missilou (Lang 60’), Gardner, Baxter, Miller (O’Grady 72’), Surridge
Carlisle United
Collin, Liddle, Gerrard ©, Parkes, Jones (Glendon 81’), Hope, Gillesphey, Yates, Sowerby (Slater 90+4’), Etuhu, Nadeson (Campbell 81’)